Repeated dose toxicity of deltamethrin in rats

Deltamethrin is a synthetic pyrethroid with potent insecticidal property. The technical grade deltamethrin comprises of eight stereomeric esters (four cis and four trans isomers) of the dibromo analogue of chrysanthemic acid, 2,2dimethyl-3-cyclopropanecarboxylic acids. Deltamethrin is extensively used as an ectoparasiticide in animals and as insecticides in crop production and public health programme. Some of the toxic actions of deltamethrin have been reported earlier, but reports on tissue residue level and effects after repeated daily oral administration on cytochrome P450, cytochrome b 5 , antioxidant status, blood biochemistry and histology of some tissues in rats are scarcely available. It has been recorded that the vehicle has a great influence on the LD 50 , probably by influencing absorption. The oral LD 50 values of deltamethrin for rats were 52 mg/kg (in peanut oil) and 67 mg/kg (in polyethylene glycol 200). [1] The dimethyl sulphoxide (DMSO) is not used in the commercial formulation, but it is one of the vehicles in which alpha-cypermethrin (αCP) is dissolved whenever it is used. The DMSO is used as a solvent for any organic compounds including α-CP. Yet the LD 50 Repeated dose toxicity of deltamethrin in rats